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Inclusion criteria were a serum thyroid stimulating hormone (TSH) concentration of 10 in infective hepatitis. Patients of ≥18 years old receiving medical care at a large, academic, urban US medical centre between 2002-2016. Single-institution retrospective cohort study. The aim of this study was to assess the risks factors and threshold of thyrotoxicosis severity for developing an abnormal liver biochemical test upon the diagnosis of new thyrotoxicosis. There is a wide range of the incidence of these abnormalities in the published literature. Lin, Tiffany Y Shekar, Anshula O Li, Ning Yeh, Michael W Saab, Sammy Wilson, Mark Leung, Angela MĪbnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen the severity of the abnormal serum liver biochemistries. Incidence of abnormal liver biochemical tests in hyperthyroidism. For permission to use (where not already granted under a licence) please go to
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Published by the BMJ Publishing Group Limited. In this review, we discuss the interpretation of the routinely performed liver tests along with the indications and utility of quantitative tests.
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Severity of liver injury is best assessed by composite scores like the Model for End Stage Liver Disease rather than any single parameter. A combination of a careful history and clinical examination along with interpretation of pattern of liver test abnormalities can often identify type and aetiology of liver disease, allowing for a targeted investigation approach. Also, many of these tests like liver enzyme levels do not measure the function of the liver, but are markers of liver injury, which is broadly of two types: hepatocellular and cholestatic. Many of these patients do not have primary liver disease as most of the commonly performed markers are not specific for the liver and are affected by myriad factors unrelated to liver disease. Incidentally detected abnormality in liver function tests is a common situation encountered by physicians across all disciplines. Evaluation of abnormal liver function tests.Īgrawal, Swastik Dhiman, Radha K Limdi, Jimmy K